Global assays of fibrinolysis

Challenges of PTH Assays

Parathyroid hormone (PTH) plays a vital role in regulating of blood Calcium. In addition, it regulates the amount of phosphate and vitamin D in the blood. PTH is a polypeptide hormone that found in the blood circulation as peptides with different amino acid counts. The active form of the PTH which has biological activity, contains 84 amino acids, but under the influence of proteolytic enzymes...

Global assays and the management of oral anticoagulation

Coagulation tests range from global or overall tests to assays specific to individual clotting factors and their inhibitors. Whether a particular test is influenced by an oral anticoagulant depends on the principle of the test and the type of oral anticoagulant. Knowledge on coagulation tests applicable in monitoring status and reversal of oral anticoagulation is a prerequisite when studying po...

Biological role of fibrinolysis.

Fibrinolysis is a basic defence mechanism of the organism designed to control the deposition of fibrin in the vascular system and elsewhere. When thrombin is generated by the coagulation system it acts on fibrinogen and 'precipitates' it out of solution as a polymer-fibrin. This polymer deposition is regulated by the fibrinolytic system which acts on the insoluble protein fibrin and, by splitti...

Natural inhibitors of fibrinolysis.

Pharmacology of fibrinolysis.

Fibrinolytic therapy has an expanding role in the treatment of many thromboembolic disorders. Four fibrinolytic drugs are currently marketed: streptokinase, anisoylated plasminogen-streptokinase activator complex, urokinase, and recombinant human tissue-type plasminogen activator. All 4 of these drugs activate the fibrinolytic system by converting plasminogen to the active enzyme, plasmin. Plas...